Think about it this way, anon. A rare Weak boon on attack gives around 87% additional damage. The sword deals around 20-30 damage. That means the aphro Weak boon gives you anywhere from 17 to 26 extra damage per strike. You can upgrade it using poms, but keep in mind poms have really diminishing returns after the first upgrade. so we'll say every + damage boon besides Artemis effectively doubles your damage.
Now Doom(common rarity) deals 50 damage. Doom is unique in that it gets a lot of augmentation boons, and the highest I've gotten was ~600-ish damage per doom proc, and that's not counting the duo boon with Weak to get consecutive attacks.
Hangover deals anyways from 4 to 8 damage per proc. It procs 8 times for full duration, for 32 to 64 damage. And it can stack 5(8 if you're using the Weak duo boon) times, upping that damage to 160-320 damage per four seconds.
I will concede that on stronger/slower attacking weapons like Arthur/Guan Yu/Gilgamesh, straight up damage boons are much stronger because the percentages count for more then.
But really I don't think you should be picky, and just pick whatever catches your fancy.